METABOLIC CHANGES IN WOMEN AND MEN WITH TYPE 2 DM ON ISLGT-2 TREATMEN

The use of morpho-metabolic approaches has a great practical importance in evaluation the effectiveness antihyperglycemic therapy clinical trials, particular those related to new classes inhibitors sodiumdependent glucose-2 cotransporter that have ability counteract many diabetic complications and cardiovascular disease. aim study was effect treatment with SLGT2 on morphological metabolic parameters men women type 2 diabetes. Materials methods. During study, 205 patients diabetes, aged 30 81, disease duration 1 20 years were examined. Patients underwent examination Department Age Endocrinology Clinical Pharmacology Institute Metabolism. V.P. Komissarenko National Academy Medical Sciences Ukraine. received antihyperglycemic, antihypertensive dyslipidemic therapy. Results.The anthropometric, biochemical groups diabetes dynamics longterm (12 month) iSLGT2- dapagliflozin allowed identify certain sexual characteristics effects this drug. In group been seen gradual decrease visceral fat levels during A BMI, BP, body weight uricemia is most likely associated abdominal obesity decreased insulin secretion. showed significant total fat, accompanied by relative water content, muscle bone mass. Conclusions. Treatment drugs iSLGT2 for 12 months reduced degree improved some indicators composition, uric acid.